Linked Life Data

12961084

Source:http://linkedlifedata.com/resource/pubmed/id/12961084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-10-30
pubmed:abstractText
Water transport across cell membranes is a fundamental biological problem. In the kidney, many nephron segments have mechanisms for transporting large quantities of water with minimal energy input. The proximal tubule reabsorbs two-thirds of the glomerular filtrate with a small transepithelial osmotic gradient as the driving force. In the adult proximal tubule, this is accomplished by the expression of aquaporin 1 (AQP1), the water channel located on the apical and basolateral membranes of the proximal tubule. The neonatal tubule has a much lower expression of AQP1, yet can still transport water with a small osmotic gradient. Thus, tubule properties other than AQP1 expression must allow for this to occur. There are two primary differences that account for this unexpectedly high osmotic water permeability of the neonatal proximal tubule. First, the lipid membrane of the neonatal tubule is more fluid than the adult tubule and therefore a larger fraction of the water can pass through the lipid bilayer. The second property is the fact that the neonatal tubule cells have a smaller cell volume, and thus, the intracellular compartment provides less resistance for the movement of water. This review will discuss postnatal maturation of proximal tubule water transport.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1089-94
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Ontogeny of water transport in the rabbit proximal tubule.
pubmed:affiliation
Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9063 USA. Raymond.Quigley@UTSouthwestern.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't