|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0439097,
umls-concept:C0600370,
umls-concept:C0805586,
umls-concept:C0851285,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-9-8
|
|
pubmed:abstractText |
The Vgamma4(+) pulmonary subset of gammadelta T cells regulates innate airway responsiveness in the absence of alphabeta T cells. We now have examined the same subset in a model of allergic airway disease, OVA-sensitized and challenged mice that exhibit Th2 responses, pulmonary inflammation, and airway hyperreactivity (AHR). In sensitized mice, Vgamma4(+) cells preferentially increased in number following airway challenge. Depletion of Vgamma4(+) cells before the challenge substantially increased AHR in these mice, but had no effect on airway responsiveness in normal, nonchallenged mice. Depletion of Vgamma1(+) cells had no effect on AHR, and depletion of all TCR-delta(+) cells was no more effective than depletion of Vgamma4(+) cells alone. Adoptively transferred pulmonary lymphocytes containing Vgamma4(+) cells inhibited AHR, but lost this ability when Vgamma4(+) cells were depleted, indicating that these cells actively suppress AHR. Eosinophilic infiltration of the lung and airways, or goblet cell hyperplasia, was not affected by depletion of Vgamma4(+) cells, although cytokine-producing alphabeta T cells in the lung increased. These findings establish Vgamma4(+) gammadelta T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
pubmed-author:AydintugM KemalMK,
pubmed-author:GelfandErwin WEW,
pubmed-author:HahnYoun-SooYS,
pubmed-author:JinNiyunN,
pubmed-author:LahnMichaelM,
pubmed-author:O'BrienRebecca LRL,
pubmed-author:ParkJung-WonJW,
pubmed-author:RoarkChristina LCL,
pubmed-author:TakedaKatsuyukiK,
pubmed-author:TaubeChristianC,
pubmed-author:WandsJ MJM,
pubmed-author:WilmoreDD
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
171
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3170-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12960345-Adoptive Transfer,
pubmed-meshheading:12960345-Animals,
pubmed-meshheading:12960345-Bronchial Hyperreactivity,
pubmed-meshheading:12960345-Cytokines,
pubmed-meshheading:12960345-Female,
pubmed-meshheading:12960345-Goblet Cells,
pubmed-meshheading:12960345-Hyperplasia,
pubmed-meshheading:12960345-Immunization,
pubmed-meshheading:12960345-Injections, Intraperitoneal,
pubmed-meshheading:12960345-Lymphocyte Count,
pubmed-meshheading:12960345-Lymphocyte Depletion,
pubmed-meshheading:12960345-Methacholine Chloride,
pubmed-meshheading:12960345-Mice,
pubmed-meshheading:12960345-Mice, Inbred BALB C,
pubmed-meshheading:12960345-Mice, Inbred C57BL,
pubmed-meshheading:12960345-Mice, Knockout,
pubmed-meshheading:12960345-Ovalbumin,
pubmed-meshheading:12960345-Pulmonary Alveoli,
pubmed-meshheading:12960345-Pulmonary Eosinophilia,
pubmed-meshheading:12960345-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:12960345-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12960345-T-Lymphocyte Subsets,
pubmed-meshheading:12960345-Up-Regulation
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice.
|
|
pubmed:affiliation |
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
