Linked Life Data

12960028

Source:http://linkedlifedata.com/resource/pubmed/id/12960028

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Stress hyperglycemia is frequent in critically ill patients. The aim of this study was to investigate the effect of blood glucose control with insulin on endocrine, metabolic, and immune function in an animal model of severe injury. Seventy-two hours after alloxan injection and exogenous insulin infusion combined with continuous iv parenteral nutrition, male New Zealand White rabbits received a burn injury and were allocated to a normoglycemic (n = 17) or hyperglycemic (n = 13) group. In the normoglycemic group, blood glucose levels were kept between 3.3 and 6.1 mmol/liter by insulin infusion, whereas in the hyperglycemic group blood glucose levels were maintained at 13.8-16.6 mmol/liter. Blood was drawn for biochemical analysis at regular time points. At 24 and 72 h after burn injury, immune function of monocytes was assessed in vitro. Maintenance of normoglycemia with exogenous insulin after severe trauma to a large extent prevented weight loss, lactic acidosis, and hyponatremia. Furthermore, within 3 d after injury, the intervention improved phagocytosis of monocytes investigated in fresh cells by more than a mean 150% (P = 0.006) and after 24-h incubation with or without lipopolysaccharide by more than a mean 4-fold (P = 0.001) and 2-fold (P = 0.05), respectively. Oxidative killing after 24-h incubation was also improved by 2-fold (P = 0.05), but no effect on chemotaxis was detected. Concomitantly, inflammation and stress-induced growth hormone hypersecretion were suppressed. Prevention of catabolism, acidosis, excessive inflammation, and impaired innate immune function may explain previously documented beneficial effects of intensive insulin therapy on outcome of critical illness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5329-38
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12960028-Alloxan, pubmed-meshheading:12960028-Animals, pubmed-meshheading:12960028-Blood Gas Analysis, pubmed-meshheading:12960028-Blood Glucose, pubmed-meshheading:12960028-Body Weight, pubmed-meshheading:12960028-Burns, pubmed-meshheading:12960028-Critical Illness, pubmed-meshheading:12960028-Diabetes Mellitus, Experimental, pubmed-meshheading:12960028-Disease Models, Animal, pubmed-meshheading:12960028-Endocrine System, pubmed-meshheading:12960028-Growth Hormone, pubmed-meshheading:12960028-Hyperglycemia, pubmed-meshheading:12960028-Hypoglycemic Agents, pubmed-meshheading:12960028-Insulin, pubmed-meshheading:12960028-Lactic Acid, pubmed-meshheading:12960028-Lipids, pubmed-meshheading:12960028-Macrophages, pubmed-meshheading:12960028-Male, pubmed-meshheading:12960028-Parenteral Nutrition, pubmed-meshheading:12960028-Rabbits, pubmed-meshheading:12960028-Stress, Physiological
pubmed:year
2003
pubmed:articleTitle
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness.
pubmed:affiliation
Departement of Intensive Care Medicine, Burn Unit and Center for Experimental Surgery and Anesthesiology, Catholic University of Leuven, B-3000, Leuven, Belgium. Frank.Weekers@uz.kuleuven.ac.be.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't