|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5638
|
|
pubmed:dateCreated |
2003-9-5
|
|
pubmed:abstractText |
Wnt proteins, regulators of development in many organisms, bind to seven transmembrane-spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled-mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients. Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein beta-arrestin 2 (betaarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2. These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Arrestins,
http://linkedlifedata.com/resource/pubmed/chemical/Clathrin,
http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt5a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/beta-arrestin,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
5
|
|
pubmed:volume |
301
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1391-4
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12958364-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12958364-Animals,
pubmed-meshheading:12958364-Arrestins,
pubmed-meshheading:12958364-Cell Line,
pubmed-meshheading:12958364-Cell Membrane,
pubmed-meshheading:12958364-Clathrin,
pubmed-meshheading:12958364-Cytoplasm,
pubmed-meshheading:12958364-Endocytosis,
pubmed-meshheading:12958364-Frizzled Receptors,
pubmed-meshheading:12958364-Humans,
pubmed-meshheading:12958364-Mice,
pubmed-meshheading:12958364-Phosphoproteins,
pubmed-meshheading:12958364-Phosphorylation,
pubmed-meshheading:12958364-Protein Kinase C,
pubmed-meshheading:12958364-Proteins,
pubmed-meshheading:12958364-Proto-Oncogene Proteins,
pubmed-meshheading:12958364-RNA, Small Interfering,
pubmed-meshheading:12958364-Recombinant Fusion Proteins,
pubmed-meshheading:12958364-Signal Transduction,
pubmed-meshheading:12958364-Wnt Proteins
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
