Linked Life Data

12958233

Source:http://linkedlifedata.com/resource/pubmed/id/12958233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-9-5
pubmed:abstractText
We recently identified the genes responsible for the serotype c-specific glucose side chain formation of rhamnose-glucose polysaccharide (RGP) in Streptococcus mutans. These genes were located downstream from the rgpA through rgpF locus that is involved in the synthesis of RGP. In the present study, the corresponding chromosomal regions were isolated from serotype e and f strains and characterized. The rgpA through rgpF homologs were well conserved among the three serotypes. By contrast, the regions downstream from the rgpF homolog differed considerably among the three serotypes. Replacement of these regions in the different serotype strains converted their serotypic phenotypes, suggesting that these regions participated in serotype-specific glucose side chain formation in each serotype strain. Based on the differences among the DNA sequences of these regions, a PCR method was developed to determine serotypes. S. mutans was isolated from 198 of 432 preschool children (3 to 4 years old). The serotypes of all but one S. mutans isolate were identified by serotyping PCR. Serotype c predominated (84.8%), serotype e was the next most common (13.3%), and serotype f occured rarely (1.9%) in Japanese preschool children. Caries experience in the group with a mixed infection by multiple serotypes of S. mutans was significantly higher than that in the group with a monoinfection by a single serotype.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-10515952, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-11154412, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-11695754, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-12010977, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-12459482, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-13578996, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-2333095, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-3017865, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-3540569, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-7785991, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-8407794, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-8712973, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-9023194, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-9209063, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-9611798, http://linkedlifedata.com/resource/pubmed/commentcorrection/12958233-9791140
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4107-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Analysis of loci required for determination of serotype antigenicity in Streptococcus mutans and its clinical utilization.
pubmed:affiliation
Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't