Linked Life Data

12957223

Source:http://linkedlifedata.com/resource/pubmed/id/12957223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-9-5
pubmed:abstractText
This study examined the effects of the cannabinoid CB(1) receptor agonist (R)-methanandamide and the CB(1) receptor antagonist SR-141716 on open-field behaviors in rats. Animals were examined after administration of (R)-methanandamide (dose range 10 to 30 mg/kg) plus vehicle, and the two drugs in combination; the dose range of SR-141716 was 0.3 to 5.6 mg/kg. Injections were given intraperitoneally 20 min prior to initial testing. Additional exposures to the open-field arena occurred for the groups treated with 30 mg/kg (R)-methanandamide at 60 and 120 min post administration. There was a dose-related suppression of ambulation (horizontal activity) and rearing (vertical activity) after (R)-methanandamide administration. Coadministration of SR-141716 did not counteract the suppression induced by 10 and 18 mg/kg (R)-methanandamide but rather tended to augment it, especially with regard to ambulation using SR-141716 doses of 1 mg/kg and up. The latency to leave the starting area in the center of the field was significantly elevated by 30 mg/kg (R)-methanandamide. This effect was completely blocked by SR-141716. With increasing doses of SR-141716, there was an increase in grooming and scratching. Generally, the strongest effects occurred 20 min post administration with the exception of grooming, which reached maximum at 60 min post. Differences in the number of circlings, vocalizations, urination, and defecation generally did not differ clearly among treatments. These results coupled with previous open-field data examining combinations of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and SR-141716 [Pharmacol. Biochem. Behav. 73 (2002) 911] underscore pharmacological differences between (R)-methanandamide and Delta(9)-THC revealed by their interactions with SR-141716.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
809-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.
pubmed:affiliation
Department of Psychology, Temple University, Philadelphia, PA 19122, USA. tjarbe@astro.temple.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.