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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1976-4-15
|
| pubmed:abstractText |
The abnormal aggregates of fibrillar material found in neurons in Alzheimer's disease, senile dementia, the Guam Parkinsonism-Dementia complex, Down's syndrome, and postencephalitic Parkinsonism were studied by means of tilt-stage electron microscopy and with X-ray images of scale models of a bifilar helix. The model fulfills the structural criteria established by electron microscopy. These studies showed that the "twisted tubule" which makes up the neurofibrillary tangle in many pathological situations is a bifilar helix made up of 130 A filaments.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-510X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
173-81
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:129541-Alzheimer Disease,
pubmed-meshheading:129541-Brain Diseases,
pubmed-meshheading:129541-Dementia,
pubmed-meshheading:129541-Down Syndrome,
pubmed-meshheading:129541-Humans,
pubmed-meshheading:129541-Neurofibrils,
pubmed-meshheading:129541-Parkinson Disease,
pubmed-meshheading:129541-Parkinson Disease, Postencephalitic
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Neurofibrillary tangles of paired helical filaments.
|
| pubmed:publicationType |
Journal Article
|