Source:http://linkedlifedata.com/resource/pubmed/id/12954069
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2003-9-4
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| pubmed:abstractText |
A series of soft quaternary ammonium antimicrobial agents, which are analogues to currently used quaternary ammonium preservatives such as cetyl pyridinium chloride and benzalkonium chloride, were synthesized. These soft analogues consist of long alkyl chain connected to a polar headgroup via chemically labile spacer group. They are characterized by facile nonenzymatic and enzymatic degradation to form their original nontoxic building blocks. However, their chemical stability has to be adequate in order for them to have antimicrobial effects. Stability studies and antibacterial and antiviral activity measurements revealed relationship between activity, lipophilicity, and stability. Their minimum inhibitory concentration (MIC) was as low as 1 microg/mL, and their viral reduction was in some cases greater than 6.7 log. The structure-activity studies demonstrate that the bioactive compounds (i.e., MIC for Gram-positive bacteria of <10 microg/mL) have an alkyl chain length between 12 and 18 carbon atoms, with a polar headgroup preferably of a small quaternary ammonium group, and their acquired inactivation half-life must be greater than 3 h at 60 degrees C.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzalkonium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cetylpyridinium,
http://linkedlifedata.com/resource/pubmed/chemical/Quaternary Ammonium Compounds
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0022-2623
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
46
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4173-81
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12954069-Alkylation,
pubmed-meshheading:12954069-Animals,
pubmed-meshheading:12954069-Anti-Bacterial Agents,
pubmed-meshheading:12954069-Anti-Infective Agents,
pubmed-meshheading:12954069-Benzalkonium Compounds,
pubmed-meshheading:12954069-Cercopithecus aethiops,
pubmed-meshheading:12954069-Cetylpyridinium,
pubmed-meshheading:12954069-Drug Stability,
pubmed-meshheading:12954069-Enterococcus faecalis,
pubmed-meshheading:12954069-Escherichia coli,
pubmed-meshheading:12954069-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:12954069-Microbial Sensitivity Tests,
pubmed-meshheading:12954069-Pseudomonas aeruginosa,
pubmed-meshheading:12954069-Quaternary Ammonium Compounds,
pubmed-meshheading:12954069-Simplexvirus,
pubmed-meshheading:12954069-Staphylococcus aureus,
pubmed-meshheading:12954069-Structure-Activity Relationship,
pubmed-meshheading:12954069-Vero Cells
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Soft antimicrobial agents: synthesis and activity of labile environmentally friendly long chain quaternary ammonium compounds.
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| pubmed:affiliation |
Faculty of Pharmacy, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. thorstlo@hi.is
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|