12953805

Source:http://linkedlifedata.com/resource/pubmed/id/12953805

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002871, umls-concept:C0026764, umls-concept:C0162340, umls-concept:C0332185, umls-concept:C0699748, umls-concept:C0725066
pubmed:issue	2
pubmed:dateCreated	2003-9-4
pubmed:abstractText	Anemia is a prominent feature of multiple myeloma (MM) and is commonly associated with clinical progression of MM. In addition to being affected by a number of pathogenetic events, including imbalance of the cytokine network, inappropriate erythropoietin (EPO) levels, blood loss, and hemolysis, the erythroid matrix is chronically deteriorated by the malignant plasma cell clone that activates a cytotoxic mechanism directed at the erythroid progenitors. In particular, malignant plasma cells express very high levels of apoptogenic receptors, including both Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, which trigger apoptosis of immature erythroblasts by stimulating specific death receptors, namely Fas and the complex DR4/DR5. Erythroid cells also weakly express the transcription factor GATA-1, which drives erythroblast maturation by inhibiting apoptosis through antiapoptotic molecules such as EPO and Bcl-xL. This newly discovered pathogenetic mechanism of anemia in MM is based on persistent erythroblast cytotoxicity within the bone marrow that leads to progressive destruction of the erythroid matrix.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9111627
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0925-5710
pubmed:author	pubmed-author:DammaccoFrancoF, pubmed-author:QuatraroCosimaC, pubmed-author:SilvestrisFrancoF, pubmed-author:TucciMarcoM
pubmed:issnType	Print
pubmed:volume	78
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	121-5
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12953805-Anemia, pubmed-meshheading:12953805-Humans, pubmed-meshheading:12953805-Multiple Myeloma
pubmed:year	2003
pubmed:articleTitle	Recent advances in understanding the pathogenesis of anemia in multiple myeloma.
pubmed:affiliation	DIMO, Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy. f.silvestris@dimo.uniba.it
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't