Linked Life Data

12951642

Source:http://linkedlifedata.com/resource/pubmed/id/12951642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-9-2
pubmed:abstractText
Hypoglycemia is a profound threat to the brain since glucose is its preferred fuel. Thus, decreases in plasma glucose must be sensed and appropriate hormonal and neuroendocrine responses generated to restore glucose to safe levels (i.e. counterregulatory responses (CRR) to hypoglycemia). Recurrent hypoglycemia impairs these protective mechanisms, resulting in a potentially life-threatening condition known as hypoglycemia-associated autonomic failure (HAAF). During HAAF, the glycemic threshold is reset so that glucose levels must fall further before the CRR is initiated. The brain plays a critical role in sensing hypoglycemia and initiating the CRR. Additionally, many neurons may sense changes in plasma and extracellular glucose. However, the way in which central glucose sensing is integrated to lead to effective initiation of the CRR is unknown. Furthermore, the mechanisms by which this system becomes impaired during HAAF are also unknown. Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) are poised to serve an integrative function in glucose homeostasis. First, they sense glucose. Second, the VMN receives input from other glucose-sensing areas. Finally, the VMN projects to areas linked to the regulation of the sympathoadrenal system that mediates the CRR. This review discusses VMN glucosensing neurons relative to their capacity to play a role in the regulation of the CRR and the generation of HAAF. Glucosensing neurons in the hindbrain as well as peripheral glucosensors are also considered.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1520-7552
pubmed:author
pubmed:copyrightInfo
Copyright 2003 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
348-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) and hypoglycemia-associated autonomic failure (HAAF).
pubmed:affiliation
Departments of Pharmacology & Physiology and Neurosciences, New Jersey Medical School (UMDNJ), Newark, NJ 07103, USA. routhvh@umdnj.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't