Linked Life Data

12951543

Source:http://linkedlifedata.com/resource/pubmed/id/12951543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-9-2
pubmed:abstractText
Sexual transmission of HIV is the principal mode of spread of HIV throughout the world. Whether the use of combination antiretroviral therapy will affect the sexual transmission of HIV remains to be seen. For an effect to occur, the viral load reductions seen within the blood need to be mirrored at a mucosal level, within the rectal tissues, the female genital tract and the semen of HIV-1-infected men. In part, this will be determined by the local concentrations of drugs within the genital tract. In this overview, we summarise the current knowledge on antiretroviral drug penetration into the male and female genital tracts. We also review studies that have investigated the effect of antiretroviral therapy on genital-tract shedding. The clinical implications of these studies are discussed. We conclude that the risk of HIV transmission exists as a spectrum, with many factors, both behavioural and biological, at interplay. It is conceivable that the use of antiretroviral therapy could reduce the spread of HIV from certain individuals. However, this idea is based on biological plausibility and surrogate marker data, rather than prospective population studies. In the worst-case scenario, antiretroviral therapy may simply increase the transmission of drug-resistant virus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1462-0308
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-66
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Antiretroviral therapy to reduce the sexual transmission of HIV.
pubmed:affiliation
Department of Sexual Medicine, Brimingham Heartlands Hospital, Birmingham B9 5SS, UK. s.taylor.1@bham.ac.uk
pubmed:publicationType
Journal Article, Review