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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-9-2
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pubmed:abstractText |
The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkenes,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxy Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrous Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Iron Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Terphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/leucomentin-5,
http://linkedlifedata.com/resource/pubmed/chemical/leucomentin-6
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1813-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12951520-Agaricales,
pubmed-meshheading:12951520-Alkenes,
pubmed-meshheading:12951520-Animals,
pubmed-meshheading:12951520-DNA Damage,
pubmed-meshheading:12951520-Epoxy Compounds,
pubmed-meshheading:12951520-Ferrous Compounds,
pubmed-meshheading:12951520-Free Radicals,
pubmed-meshheading:12951520-Glutamic Acid,
pubmed-meshheading:12951520-Hydrogen Peroxide,
pubmed-meshheading:12951520-Iron Chelating Agents,
pubmed-meshheading:12951520-Lipid Peroxidation,
pubmed-meshheading:12951520-Mice,
pubmed-meshheading:12951520-Mice, Inbred ICR,
pubmed-meshheading:12951520-N-Methylaspartate,
pubmed-meshheading:12951520-Neurons,
pubmed-meshheading:12951520-Neuroprotective Agents,
pubmed-meshheading:12951520-Rats,
pubmed-meshheading:12951520-Terphenyl Compounds
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pubmed:year |
2003
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pubmed:articleTitle |
Neuroprotective activity of p-terphenyl leucomentins from the mushroom Paxillus panuoides.
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pubmed:affiliation |
Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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