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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-9-1
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pubmed:abstractText |
Prostate-specific gene ablation provides a powerful tool for functional characterization of genes that have impact on embryonic development or on other organs, specifically in the prostate. Uniform expression of Cre with high recombinase activity in the prostate is needed for prostate-specific gene ablation based on Cre-loxP recombinations. Currently, available strains of Cre transgenic mice only express Cre recombinase adequately in certain lobes of the prostate. In other lobes, the expression is low and mosaic. Additional strains of transgenic mice expressing high levels of prostate-specific Cre in all prostate lobes would be useful to study the impact of genome manipulation in all prostate lobes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/FGFR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
160-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12949940-Animals,
pubmed-meshheading:12949940-Chickens,
pubmed-meshheading:12949940-Gene Deletion,
pubmed-meshheading:12949940-Gene Expression,
pubmed-meshheading:12949940-Humans,
pubmed-meshheading:12949940-Integrases,
pubmed-meshheading:12949940-Male,
pubmed-meshheading:12949940-Mice,
pubmed-meshheading:12949940-Mice, Inbred Strains,
pubmed-meshheading:12949940-Mice, Knockout,
pubmed-meshheading:12949940-Mice, Transgenic,
pubmed-meshheading:12949940-Promoter Regions, Genetic,
pubmed-meshheading:12949940-Prostate,
pubmed-meshheading:12949940-Receptor, Fibroblast Growth Factor, Type 2,
pubmed-meshheading:12949940-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:12949940-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:12949940-Seminal Vesicles,
pubmed-meshheading:12949940-Tissue Distribution,
pubmed-meshheading:12949940-Vas Deferens,
pubmed-meshheading:12949940-Viral Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Transgenic mouse with high Cre recombinase activity in all prostate lobes, seminal vesicle, and ductus deferens.
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pubmed:affiliation |
Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030-3303, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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