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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-9-1
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pubmed:abstractText |
Prostate specific membrane antigen or PSMA has been recognized as one of the important cellular markers for prostate cancer, the expression of which is enhanced many fold in prostate cancer and other tumor neovasculature. PSMA is a type II membrane glycoprotein with a short cytoplasmic N-terminal region, a transmembrane domain, and a 701 amino acid extracellular portion with 10 potential N-linked glycosylation sites. PSMA is a folate hydrolase, which cleaves terminal glutamates from poly- and gamma-glutamated folates; and NAALADase, which hydrolyses alpha-glutamate-linked dipeptide, N-acetyl-aspartyl-glutamate (NAAG) and is a glutamate carboxypeptidase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Asparagine,
http://linkedlifedata.com/resource/pubmed/chemical/Carboxypeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Carboxypeptidase II,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosaminidases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tunicamycin,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate carboxypeptidase II, human
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12949938-Alanine,
pubmed-meshheading:12949938-Antigens, Surface,
pubmed-meshheading:12949938-Asparagine,
pubmed-meshheading:12949938-Carbohydrate Metabolism,
pubmed-meshheading:12949938-Carboxypeptidases,
pubmed-meshheading:12949938-Drug Stability,
pubmed-meshheading:12949938-Folic Acid,
pubmed-meshheading:12949938-Glutamate Carboxypeptidase II,
pubmed-meshheading:12949938-Glycosylation,
pubmed-meshheading:12949938-Hexosaminidases,
pubmed-meshheading:12949938-Humans,
pubmed-meshheading:12949938-Hydrolysis,
pubmed-meshheading:12949938-Microscopy, Confocal,
pubmed-meshheading:12949938-Molecular Conformation,
pubmed-meshheading:12949938-Mutagenesis, Site-Directed,
pubmed-meshheading:12949938-Mutation,
pubmed-meshheading:12949938-Recombinant Proteins,
pubmed-meshheading:12949938-Tissue Distribution,
pubmed-meshheading:12949938-Tumor Cells, Cultured,
pubmed-meshheading:12949938-Tunicamycin
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pubmed:year |
2003
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pubmed:articleTitle |
Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.
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pubmed:affiliation |
George O'Brien Center for Urology Research, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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