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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-9-1
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pubmed:abstractText |
Steroid 5alpha-reductase 2 (SRD5A2) catalyzes the conversion of testosterone to the more potent androgen, DHT, in the prostate. The therapeutic influence of SRD5A2 inhibitor finasteride on prostate cancer is currently unknown. The direction and extent of changes in SRD5A2 expression in disease tissues is a relevant issue in this regard.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12949937-Case-Control Studies,
pubmed-meshheading:12949937-Cholestenone 5 alpha-Reductase,
pubmed-meshheading:12949937-Databases, Genetic,
pubmed-meshheading:12949937-Enzyme Inhibitors,
pubmed-meshheading:12949937-Finasteride,
pubmed-meshheading:12949937-Gene Expression,
pubmed-meshheading:12949937-Gene Expression Profiling,
pubmed-meshheading:12949937-Humans,
pubmed-meshheading:12949937-Male,
pubmed-meshheading:12949937-Nucleic Acid Amplification Techniques,
pubmed-meshheading:12949937-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12949937-Oxidoreductases,
pubmed-meshheading:12949937-Prostatic Hyperplasia,
pubmed-meshheading:12949937-Prostatic Neoplasms,
pubmed-meshheading:12949937-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2003
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pubmed:articleTitle |
Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma.
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pubmed:affiliation |
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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