Linked Life Data

12949645

Source:http://linkedlifedata.com/resource/pubmed/id/12949645

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-9-1
pubmed:abstractText
In vitro incorporation of tranquilizer phenazepam in a concentration of 10(-13) M into membrane fraction from mouse brain produced a prooxidant effect. In concentrations of 10(-5)-10(-9) and 10(-15)-10(-17) M this agent possessed antioxidant activity. Phenazepam significantly decreased the maximum rate of enzymatic reactions (10(-5) and 10(-15) M) and Michaelis constant (10(-5) M) for acetylcholinesterase. Incorporation of phenazepam in ultralow doses into membrane modified its lipid components (estimated by lipid peroxidation) and functional state, and this effect was comparable with the influence of this substance in standard doses. This probably contributes to the physiological effect of ultralow doses of phenazepam in.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1573-8221
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
135 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-4
pubmed:dateRevised
2009-9-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Phenazepam in therapeutic and ultralow doses in vitro modulates the content of lipid peroxidation products and acetylcholinesterase activity in membrane fraction from mouse brain.
pubmed:affiliation
N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
pubmed:publicationType
Journal Article