| pubmed-article:12949531 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C1708627 | lld:lifeskim |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C0064847 | lld:lifeskim |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C1334350 | lld:lifeskim |
| pubmed-article:12949531 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:12949531 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12949531 | pubmed:dateCreated | 2003-9-29 | lld:pubmed |
| pubmed-article:12949531 | pubmed:abstractText | Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment. | lld:pubmed |
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| pubmed-article:12949531 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12949531 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12949531 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12949531 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12949531 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:LusterAndrew... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:TagerAndrew... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:GersztenRober... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:FriedrichErik... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:BromleyShanno... | lld:pubmed |
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| pubmed-article:12949531 | pubmed:author | pubmed-author:CarafoneAndre... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:IslamSabina... | lld:pubmed |
| pubmed-article:12949531 | pubmed:author | pubmed-author:BercuryScott... | lld:pubmed |
| pubmed-article:12949531 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12949531 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12949531 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12949531 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12949531 | pubmed:pagination | 982-90 | lld:pubmed |
| pubmed-article:12949531 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12949531 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12949531 | pubmed:articleTitle | Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. | lld:pubmed |
| pubmed-article:12949531 | pubmed:affiliation | Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. | lld:pubmed |
| pubmed-article:12949531 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12949531 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12949531 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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