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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-9-29
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pubmed:abstractText |
Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
982-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12949531-Animals,
pubmed-meshheading:12949531-Asthma,
pubmed-meshheading:12949531-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12949531-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12949531-Chemotaxis, Leukocyte,
pubmed-meshheading:12949531-Disease Models, Animal,
pubmed-meshheading:12949531-Female,
pubmed-meshheading:12949531-Flow Cytometry,
pubmed-meshheading:12949531-Immunoglobulin E,
pubmed-meshheading:12949531-Immunoglobulin G,
pubmed-meshheading:12949531-Leukotriene B4,
pubmed-meshheading:12949531-Lymphocyte Activation,
pubmed-meshheading:12949531-Male,
pubmed-meshheading:12949531-Mice,
pubmed-meshheading:12949531-Mice, Inbred C57BL,
pubmed-meshheading:12949531-Mice, Knockout,
pubmed-meshheading:12949531-Receptors, Leukotriene B4,
pubmed-meshheading:12949531-T-Lymphocyte Subsets
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pubmed:year |
2003
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pubmed:articleTitle |
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.
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pubmed:affiliation |
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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