Linked Life Data

12949013

Source:http://linkedlifedata.com/resource/pubmed/id/12949013

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-8
pubmed:abstractText
Circulating IGF-I is correlated with fitness, but results of prospective exercise training studies have been inconsistent, showing both increases and decreases in IGF-I. We hypothesized that energy balance, often not accounted for, is a regulating variable such that training plus an energy intake deficit would cause a reduction in IGF-I, whereas training plus energy intake excess would lead to an increased IGF-I. To test this, 19 young, healthy men completed a 7-day strenuous exercise program in which they were randomly assigned to either a positive energy balance [overfed (OF), n = 10] or negative energy balance [underfed (UF), n = 9] group. IGF-I (free and total), insulin, and IGF-binding protein-1 were measured before, during, and 1 wk after the training. Weight decreased in the UF subjects and increased in the OF subjects. Free and total IGF-I decreased substantially in the UF group (P < 0.0005 for both), but, in the OF group, IGF-I remained unchanged. The UF group also demonstrated an increase in IGF-binding protein-1 (P < 0.027), whereas glucose levels decreased (P < 0.0005). In contrast, insulin was reduced in both the OF and UF exercise-training groups (P < 0.044). Finally, within 7 days of the cessation of the diet and training regimen, IGF-I and IGF-binding protein-1 in the UF group returned to preintervention levels. We conclude that energy balance during periods of exercise training influences circulating IGF-I and related growth mediators. Exercise-associated mechanisms may inhibit increases in IGF-I early in the course of a training protocol, even in overfed subjects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-82
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12949013-Adolescent, pubmed-meshheading:12949013-Adult, pubmed-meshheading:12949013-Blood Glucose, pubmed-meshheading:12949013-Body Composition, pubmed-meshheading:12949013-Body Weight, pubmed-meshheading:12949013-Energy Metabolism, pubmed-meshheading:12949013-Exercise, pubmed-meshheading:12949013-Hematocrit, pubmed-meshheading:12949013-Human Growth Hormone, pubmed-meshheading:12949013-Humans, pubmed-meshheading:12949013-Insulin, pubmed-meshheading:12949013-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:12949013-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:12949013-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:12949013-Insulin-Like Growth Factor Binding Protein 4, pubmed-meshheading:12949013-Insulin-Like Growth Factor Binding Protein 6, pubmed-meshheading:12949013-Insulin-Like Growth Factor I, pubmed-meshheading:12949013-Male, pubmed-meshheading:12949013-Physical Fitness, pubmed-meshheading:12949013-Serum Albumin
pubmed:year
2004
pubmed:articleTitle
Negative energy balance plays a major role in the IGF-I response to exercise training.
pubmed:affiliation
Center for the Study of Health Effects of Exeercise in Childdren, University of California Children's Hospital, College of Medicine, Irvine, CA 92868, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't