Source:http://linkedlifedata.com/resource/pubmed/id/12948282
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2003-9-1
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| pubmed:abstractText |
Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that plays a key role in protecting the cell from oxidative damage. A polymorphism in the mitochondrial targeting sequence (a valine to alanine substitution), thought to alter transport of the enzyme into mitochondria, has been associated with increased risk for breast cancer with a more pronounced association among women with low intake of dietary antioxidants. We examined the role of MnSOD in the development of prostate cancer in a large, randomized cancer prevention trial of male smokers, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We hypothesized that MnSOD may be associated with prostate cancer and that long-term antioxidant supplementation (alpha-tocopherol 50 mg/day for five to eight years) could modify the effect on risk.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0957-5243
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
513-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12948282-Aged,
pubmed-meshheading:12948282-Antioxidants,
pubmed-meshheading:12948282-Case-Control Studies,
pubmed-meshheading:12948282-Finland,
pubmed-meshheading:12948282-Genotype,
pubmed-meshheading:12948282-Humans,
pubmed-meshheading:12948282-Logistic Models,
pubmed-meshheading:12948282-Male,
pubmed-meshheading:12948282-Middle Aged,
pubmed-meshheading:12948282-Odds Ratio,
pubmed-meshheading:12948282-Polymorphism, Genetic,
pubmed-meshheading:12948282-Prostatic Neoplasms,
pubmed-meshheading:12948282-Randomized Controlled Trials as Topic,
pubmed-meshheading:12948282-Risk Assessment,
pubmed-meshheading:12948282-Risk Factors,
pubmed-meshheading:12948282-Superoxide Dismutase,
pubmed-meshheading:12948282-alpha-Tocopherol,
pubmed-meshheading:12948282-beta Carotene
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland).
|
| pubmed:affiliation |
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-7058, USA. kw114v@nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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