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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1993-4-14
|
| pubmed:abstractText |
The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1748-55
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1294695-Acetylation,
pubmed-meshheading:1294695-Crystallization,
pubmed-meshheading:1294695-Diterpenes,
pubmed-meshheading:1294695-Glucuronidase,
pubmed-meshheading:1294695-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1294695-Methylation,
pubmed-meshheading:1294695-Molecular Conformation,
pubmed-meshheading:1294695-Paraguay,
pubmed-meshheading:1294695-Plants, Medicinal,
pubmed-meshheading:1294695-X-Ray Diffraction
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis.
|
| pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|