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rdf:type |
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lifeskim:mentions |
umls-concept:C0005823,
umls-concept:C0020538,
umls-concept:C0030705,
umls-concept:C0065374,
umls-concept:C0332170,
umls-concept:C0439841,
umls-concept:C0717550,
umls-concept:C1547135,
umls-concept:C1547139,
umls-concept:C1561560,
umls-concept:C1561561,
umls-concept:C1707455
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pubmed:issue |
5
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|
pubmed:dateCreated |
2003-8-28
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pubmed:abstractText |
We performed a prospective crossover study in 73 essential hypertensives to compare the effects of candesartan and lisinopril on ambulatory blood pressure (BP) and early-morning BP. Twenty-four-hour ambulatory BP monitoring was performed at baseline and for each active treatment. Small doses of thiazide diuretic were added as needed. The effects of both drugs on 24-hour BP were almost identical and satisfactory. When we classified patients into the morning surge group (the highest quartile of morning systolic BP surge >36 mm Hg) and the non-morning surge group (the remaining 3 quartiles of morning BP surge), candesartan was superior in decreasing morning BP and morning BP surge.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9149
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
621-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12943892-Aged,
pubmed-meshheading:12943892-Antihypertensive Agents,
pubmed-meshheading:12943892-Benzimidazoles,
pubmed-meshheading:12943892-Benzothiadiazines,
pubmed-meshheading:12943892-Blood Pressure,
pubmed-meshheading:12943892-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:12943892-Chi-Square Distribution,
pubmed-meshheading:12943892-Circadian Rhythm,
pubmed-meshheading:12943892-Cross-Over Studies,
pubmed-meshheading:12943892-Diuretics,
pubmed-meshheading:12943892-Dose-Response Relationship, Drug,
pubmed-meshheading:12943892-Drug Therapy, Combination,
pubmed-meshheading:12943892-Female,
pubmed-meshheading:12943892-Humans,
pubmed-meshheading:12943892-Hypertension,
pubmed-meshheading:12943892-Lisinopril,
pubmed-meshheading:12943892-Male,
pubmed-meshheading:12943892-Middle Aged,
pubmed-meshheading:12943892-Prospective Studies,
pubmed-meshheading:12943892-Sodium Chloride Symporter Inhibitors,
pubmed-meshheading:12943892-Systole,
pubmed-meshheading:12943892-Tetrazoles,
pubmed-meshheading:12943892-Time Factors,
pubmed-meshheading:12943892-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Comparison of candesartan with lisinopril on ambulatory blood pressure and morning surge in patients with systemic hypertension.
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pubmed:affiliation |
Department of Cardiology, Jichi Medical School, Tochigi, Japan. kazuo-eg@jichi.ac.jp
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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