| pubmed-article:12941808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12941808 | lifeskim:mentions | umls-concept:C0389003 | lld:lifeskim |
| pubmed-article:12941808 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:12941808 | lifeskim:mentions | umls-concept:C1257915 | lld:lifeskim |
| pubmed-article:12941808 | lifeskim:mentions | umls-concept:C0392337 | lld:lifeskim |
| pubmed-article:12941808 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12941808 | pubmed:dateCreated | 2003-8-27 | lld:pubmed |
| pubmed-article:12941808 | pubmed:abstractText | Membrane arachidonic acid is converted by cyclooxygenase (COX) into prostaglandin (PG) G(2) and then to PGH(2) which is subsequently metabolized to PGE(2) by PGE synthase (PGES). Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. Likewise, inducible microsomal PGES (mPGES-1) is expressed in several types of cancer, although its role in benign polyp formation has not been investigated. We demonstrated recently that most COX-2-expressing cells in the polyps are stromal fibroblasts. Here we show colocalization of COX-1, COX-2 and mPGES in the intestinal polyp stromal fibroblasts of Apc(Delta 716) mice, a model for familial adenomatous polyposis. Contrary to COX-2 that was induced only in polyps >1 mm in diameter, COX-1 was found in polyps of any size. In polyps >1 mm, not only COX-2 but also mPGES was induced in the stromal fibroblasts where COX-1 had already been expressed. Although polyp number and size were markedly reduced in COX-1 (-/-) or COX-2 (-/-) compound mutant Apc mice, both COX-2 and mPGES were induced in the COX-1 (-/-) polyps, whereas COX-1 was expressed in the COX-2 (-/-) polyps. We found also in human familial adenomatous polyposis polyps that COX-2 and mPGES were induced in the COX-1-expressing fibroblasts. On the basis of these results, we propose that COX-1 expression in the stromal cells secures the basal level of PGE(2) that can support polyp growth to approximately 1 mm, and that simultaneous inductions of COX-2 and mPGES support the polyp expansion beyond approximately 1 mm by boosting the stromal PGE(2) production. | lld:pubmed |
| pubmed-article:12941808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12941808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941808 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12941808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12941808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12941808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12941808 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12941808 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:TaketoMakoto... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:OshimaMasanob... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:OshimaHirokoH | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:SugiharaKen-i... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:LangenbachRob... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:ChuladaPatric... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:SonoshitaMasa... | lld:pubmed |
| pubmed-article:12941808 | pubmed:author | pubmed-author:TakedaHarunaH | lld:pubmed |
| pubmed-article:12941808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12941808 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12941808 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12941808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12941808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12941808 | pubmed:pagination | 4872-7 | lld:pubmed |
| pubmed-article:12941808 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12941808 | pubmed:meshHeading | pubmed-meshheading:12941808... | lld:pubmed |
| pubmed-article:12941808 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12941808 | pubmed:articleTitle | Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. | lld:pubmed |
| pubmed-article:12941808 | pubmed:affiliation | Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. | lld:pubmed |
| pubmed-article:12941808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12941808 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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