Linked Life Data

12941349

Source:http://linkedlifedata.com/resource/pubmed/id/12941349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-8-27
pubmed:abstractText
Whether or not blood transfusion exerts an immunosuppressive effect on the recipient remains an area of controversy. The mechanism to clearly explain the effect has been elusive. We have previously suggested that there may be two categories of immunosuppressive transfusion effect: one which is HLA-dependent and directed against adaptive immunity and a second category which is mild, non-specific, and directed against innate immunity. This non-specific effect might result from the infusion of apoptotic blood cells. There is solid evidence that blood cells undergo apoptotic changes during refrigerated storage. The infusion of apoptotic cells has recently been shown in animal models to be immunosuppressive. Immunosuppression resulting from the infusion of apoptotic cells may be linked to transforming growth factor beta (TGF-beta).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
T
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1473-0502
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-9
pubmed:dateRevised
2006-6-7
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Apoptosis, TGF beta and transfusion-related immunosuppression: Biologic versus clinical effects.
pubmed:affiliation
Blood Transfusion Service, J-224, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. sdzik@partners.org
pubmed:publicationType
Journal Article, Review