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12941312
Source:
http://linkedlifedata.com/resource/pubmed/id/12941312
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0006826
,
umls-concept:C0020792
,
umls-concept:C0034289
,
umls-concept:C0087111
,
umls-concept:C0243077
,
umls-concept:C0246957
pubmed:issue
18
pubmed:dateCreated
2003-8-27
pubmed:abstractText
Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate
,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/CDK4 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases
,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BreaultGloria AGA
,
pubmed-author:EllstonRebecca P ARP
,
pubmed-author:GreenStephenS
,
pubmed-author:JamesS RussellSR
,
pubmed-author:JewsburyPhilip JPJ
,
pubmed-author:MidgleyCatherine JCJ
,
pubmed-author:MinshullClaire ACA
,
pubmed-author:PauptitRichard ARA
,
pubmed-author:PeaseJ ElizabethJE
,
pubmed-author:TuckerJulie AJA
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2961-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12941312-Adenosine Triphosphate
,
pubmed-meshheading:12941312-Animals
,
pubmed-meshheading:12941312-Antineoplastic Agents
,
pubmed-meshheading:12941312-Binding Sites
,
pubmed-meshheading:12941312-Crystallography, X-Ray
,
pubmed-meshheading:12941312-Cyclin-Dependent Kinase 4
,
pubmed-meshheading:12941312-Cyclin-Dependent Kinases
,
pubmed-meshheading:12941312-Humans
,
pubmed-meshheading:12941312-Inhibitory Concentration 50
,
pubmed-meshheading:12941312-Molecular Structure
,
pubmed-meshheading:12941312-Proto-Oncogene Proteins
,
pubmed-meshheading:12941312-Pyrimidines
,
pubmed-meshheading:12941312-Structure-Activity Relationship
pubmed:year
2003
pubmed:articleTitle
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines.
pubmed:affiliation
AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
pubmed:publicationType
Journal Article