| pubmed-article:12941138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0070410 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C1327414 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12941138 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:12941138 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12941138 | pubmed:dateCreated | 2003-8-27 | lld:pubmed |
| pubmed-article:12941138 | pubmed:abstractText | Human invariant natural killer (iNK) T cells expressing an invariant Valpha24-Jalpha15 T-cell receptor (TCR) are thought to be important regulators of autoimmunity and tumour surveillance. Two major subsets of iNK T cells, CD4+ or CD4- CD8- are known to exist, but the in vivo importance of CD4 expression is unclear. Since interleukin-12 (IL-12) is a key iNK T-cell-activating cytokine, the effect of IL-12 plus or minus the T-cell growth factor IL-2 on a large panel of CD4+ versus CD4- CD8- iNK T-cell clones was examined. Strikingly, IL-12 and IL-2 significantly activated iNK T cells to secrete IL-4, interferon-gamma and granulocyte-macrophage colony-stimulating factor, and up-regulated perforin expression in the absence of TCR stimulation. Furthermore, IL-2 and IL-12 treatment resulted in a preferential increase in apoptosis of CD4- CD8- clones. Thus, independent of TCR activation, IL-2 and IL-12 can directly activate iNK T cells and provide a selective advantage to the CD4+ iNK T-cell population. | lld:pubmed |
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| pubmed-article:12941138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12941138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941138 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12941138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12941138 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12941138 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:12941138 | pubmed:author | pubmed-author:StromingerJac... | lld:pubmed |
| pubmed-article:12941138 | pubmed:author | pubmed-author:NeubergDonna... | lld:pubmed |
| pubmed-article:12941138 | pubmed:author | pubmed-author:HouRunhuaR | lld:pubmed |
| pubmed-article:12941138 | pubmed:author | pubmed-author:WilsonS... | lld:pubmed |
| pubmed-article:12941138 | pubmed:author | pubmed-author:GoloubevaOlga... | lld:pubmed |
| pubmed-article:12941138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12941138 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:12941138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12941138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12941138 | pubmed:pagination | 30-7 | lld:pubmed |
| pubmed-article:12941138 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12941138 | pubmed:meshHeading | pubmed-meshheading:12941138... | lld:pubmed |
| pubmed-article:12941138 | pubmed:meshHeading | pubmed-meshheading:12941138... | lld:pubmed |
| pubmed-article:12941138 | pubmed:meshHeading | pubmed-meshheading:12941138... | lld:pubmed |
| pubmed-article:12941138 | pubmed:meshHeading | pubmed-meshheading:12941138... | lld:pubmed |
