|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010763,
umls-concept:C0023884,
umls-concept:C0030705,
umls-concept:C0032529,
umls-concept:C0205419,
umls-concept:C0220847,
umls-concept:C0345904,
umls-concept:C0441889,
umls-concept:C0596244,
umls-concept:C0678226,
umls-concept:C0919426,
umls-concept:C1412335,
umls-concept:C1515670,
umls-concept:C1556094,
umls-concept:C1882417
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-8-27
|
|
pubmed:abstractText |
Hepatocellular carcinoma (HCC) in persons with liver cirrhosis (LC) arises following hepatitis virus infection. Alcohol may accelerate the risk of development of LC and HCC. Cytochrome p450 2E1 (CYP2E1) oxidizes ethanol to form acetaldehyde and aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde, which is carcinogenic in humans, and both alcohol-metabolizing enzymes show the genetic polymorphisms in a Japanese population.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0036-5521
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
886-93
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12940444-Adult,
pubmed-meshheading:12940444-Aged,
pubmed-meshheading:12940444-Aged, 80 and over,
pubmed-meshheading:12940444-Aldehyde Dehydrogenase,
pubmed-meshheading:12940444-Cytochrome P-450 CYP2E1,
pubmed-meshheading:12940444-Exons,
pubmed-meshheading:12940444-Female,
pubmed-meshheading:12940444-Hepatitis C,
pubmed-meshheading:12940444-Hepatitis C Antibodies,
pubmed-meshheading:12940444-Humans,
pubmed-meshheading:12940444-Japan,
pubmed-meshheading:12940444-Liver Cirrhosis,
pubmed-meshheading:12940444-Liver Neoplasms,
pubmed-meshheading:12940444-Male,
pubmed-meshheading:12940444-Middle Aged,
pubmed-meshheading:12940444-Mutation,
pubmed-meshheading:12940444-Polymorphism, Genetic,
pubmed-meshheading:12940444-RNA, Messenger,
pubmed-meshheading:12940444-Risk Factors,
pubmed-meshheading:12940444-Transcription Initiation Site
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism.
|
|
pubmed:affiliation |
Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan. katoshun@nms.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
