Linked Life Data

12939882

Source:http://linkedlifedata.com/resource/pubmed/id/12939882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-8-27
pubmed:abstractText
In experimentally infected murine peritoneal macrophages and murine macrophage-like cells J-774 with different pathogen strains of tuberculos'is, Mycobacterium tuberculosis (MBT) underwent significant morphofunctional changes. In phagocytosis, several live and mycobacteria conventionally referred by the authors to as morphotype I cells come from the environment to the macrophage. Of them, single young and intact mycobacteria are able to multiply and form at 2-3 generations morphotype II microcolonies from 3-9 mycobacteria or more in the phasolysosomes within the first 24 hours after infection. Having taken the form of small-sized cocci and coccoovals having a closely packed cytoplasm, morphotype II cells can be long present intact in the phagocytes. By losing the cellular wall under the action of lytic phagolysosomal enzymes, single mycobacteria turned into L-form or morphotype III MBT. During damage and lysis in the macrophages, single mycobacteria can preserve a part of an intact cytoplasm and genome as ultraminor forms of mycobacteria or morpho-type IV MBT.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1728-2993
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Specific features of minute structure of Mycobacteria cultured in murine macrophages].
pubmed:publicationType
Journal Article, English Abstract