Linked Life Data

1293975

Source:http://linkedlifedata.com/resource/pubmed/id/1293975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-6
pubmed:dateCreated
1993-4-8
pubmed:abstractText
It has been postulated that flunarizine (FNZ) acts on the brain through a stabilizing effect on membrane electrical activity of neurones. It has been also suggested that neurogenic events characterized by an increased tendency of nerve cells to fire, could be involved in the pathogenesis of migraine and epilepsy. The study was aimed to assess the effect of a single oral dose of FNZ (20 mg) on CNS specific functions by means of computer analysis of saccadic eye movements. The study was performed on six healthy volunteers according to a double-blind, cross-over, placebo controlled design. FNZ produced a significant reduction only of peak saccadic velocity, thus suggesting a rather specific and selective effect on the burst cells of the para-median pontine reticular formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6276
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
326-32
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Acute effect of flunarizine on saccadic eye movements.
pubmed:affiliation
Istituto di Scienze Neurologiche, I Facoltà di Medicina, Università di Napoli.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial