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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-8-26
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pubmed:abstractText |
The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed in most human breast carcinomas and interacts with the Wnt effector gamma-catenin. Here, we demonstrate that MUC1 associates constitutively with ErbB2 in human breast cancer cells and that treatment with heregulin/neuregulin-1 (HRG) increases the formation of MUC1-ErbB2 complexes. The importance of the MUC1-ErbB2 interaction is supported by the demonstration that HRG induces binding of MUC1 and gamma-catenin and targeting of the MUC1-gamma-catenin complex to the nucleolus. Significantly, nucleolar localization of gamma-catenin in response to HRG is dependent on MUC1 expression. Moreover, mutation of a RRK motif in the MUC1 cytoplasmic domain abrogates HRG-induced nucleolar localization of MUC1 and gamma-catenin. In concert with these results, we show nucleolar localization of MUC1 and gamma-catenin in human breast carcinomas but not in normal mammary ductal epithelium. These findings demonstrate that MUC1 functions in cross talk between ErbB2 and Wnt pathways by acting as a shuttle for HRG-induced nucleolar targeting of gamma-catenin.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DF3 breast-carcinoma-associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Desmoplakins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/JUP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuregulin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/gamma Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1541-7786
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-75
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12939402-Active Transport, Cell Nucleus,
pubmed-meshheading:12939402-Antigens, Neoplasm,
pubmed-meshheading:12939402-Breast Neoplasms,
pubmed-meshheading:12939402-Cell Adhesion,
pubmed-meshheading:12939402-Cell Line, Tumor,
pubmed-meshheading:12939402-Cell Nucleolus,
pubmed-meshheading:12939402-Cytoskeletal Proteins,
pubmed-meshheading:12939402-Desmoplakins,
pubmed-meshheading:12939402-Epidermal Growth Factor,
pubmed-meshheading:12939402-Female,
pubmed-meshheading:12939402-Humans,
pubmed-meshheading:12939402-Mucin-1,
pubmed-meshheading:12939402-Neoplasm Proteins,
pubmed-meshheading:12939402-Neuregulin-1,
pubmed-meshheading:12939402-Phosphorylation,
pubmed-meshheading:12939402-Protein Binding,
pubmed-meshheading:12939402-Receptor, erbB-2,
pubmed-meshheading:12939402-gamma Catenin
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pubmed:year |
2003
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pubmed:articleTitle |
Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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