rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-8-26
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pubmed:abstractText |
The exoenzyme S regulatory protein ExsA regulates a type III secretion system in Pseudomonas aeruginosa. In vitro, cytotoxic strains use this system to secrete exotoxin (Exo)U and ExoT causing cytotoxicity and inhibiting their phagocytosis by epithelial cells. Invasive P. aeruginosa secrete ExoT and ExoS, but exsA mutation has little impact on their short-term interactions with epithelia. In the present study, the contribution of these ExsA-regulated proteins toward corneal infections in vivo was investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/ExsA protein, bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors,
http://linkedlifedata.com/resource/pubmed/chemical/pseudomonas exoprotein A protein...,
http://linkedlifedata.com/resource/pubmed/chemical/toxA protein, Pseudomonas aeruginosa
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3892-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12939306-ADP Ribose Transferases,
pubmed-meshheading:12939306-Animals,
pubmed-meshheading:12939306-Bacterial Proteins,
pubmed-meshheading:12939306-Bacterial Toxins,
pubmed-meshheading:12939306-DNA-Binding Proteins,
pubmed-meshheading:12939306-Exotoxins,
pubmed-meshheading:12939306-Eye Infections, Bacterial,
pubmed-meshheading:12939306-Female,
pubmed-meshheading:12939306-Keratitis,
pubmed-meshheading:12939306-Mice,
pubmed-meshheading:12939306-Mice, Inbred C57BL,
pubmed-meshheading:12939306-Pseudomonas Infections,
pubmed-meshheading:12939306-Pseudomonas aeruginosa,
pubmed-meshheading:12939306-Trans-Activators,
pubmed-meshheading:12939306-Virulence,
pubmed-meshheading:12939306-Virulence Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Contribution of ExsA-regulated factors to corneal infection by cytotoxic and invasive Pseudomonas aeruginosa in a murine scarification model.
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pubmed:affiliation |
Morton D. Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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