Linked Life Data

12938233

Source:http://linkedlifedata.com/resource/pubmed/id/12938233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-8-25
pubmed:abstractText
Follicular and marginal zone B cells constitute the vast majority of mature B cells in the adult spleen. The inter-relationships between these two functionally and phenotypically distinct subpopulations of B cells remain unclear. In situations of decreased bone marrow B lymphopoiesis, the proportion of spleen marginal zone B cells increases, but the consequence of increasing B lymphopoiesis on marginal zone B cells has not been investigated. Using interleukin-7-transgenic mice, in which B lymphopoiesis is significantly increased, we show that the number of follicular B cells increased about fivefold but the number of marginal zone B cells decreased. Functional and phenotypic analysis, including in vivo bromodeoxyuridine labeling experiments, showed that marginal zone B cells in transgenic mice were indistinguishable from controls. Mixed radiation bone marrow chimeras showed that marginal zone B cells developed equally well from both normal and transgenic adult bone marrow B cell progenitors. Taken together, these results suggest that interleukin-7 does not influence the lineage choice between follicular and marginal zone B cells and that the number of cells in each compartment is independently regulated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2567-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
In interleukin-7-transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbers.
pubmed:affiliation
Unité 548 INSERM, DRDC, Commissariat à l'Energie Atomique-Grenoble, Grenoble, France. ceredig@dsvsud.cea.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't