Linked Life Data

12937680

Source:http://linkedlifedata.com/resource/pubmed/id/12937680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-8-25
pubmed:abstractText
The effects of glucocorticoids on monocyte morphology and function in vitro and the results of high-dose budesonide therapy in patients with non-severe bronchial asthma were analyzed. Before therapy with inhalation glucocorticosteroid (budesonide) characteristics of blood monocytes and the effects of different concentrations of prednisolone on these cells were studied in vitro by luminol-dependent chemiluminescence and computer-assisted phase-interference microscopy. High sensitivity of patients to budesonide was associated with pronounced in vitro inhibitory effect of prednisolone on monocyte activity, which was not observed in cases with delayed effects of therapy. Pronounced inhibitory effects of glucocorticoids on monocytes in vitro were observed in patients both resistant and highly sensitive to glucocorticoid therapy. Hence, the resistance of patients with non-severe asthma to high-dose budesonide therapy is not related to the weakening of the inhibitory effect of glucocorticoids on monocyte activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-4888
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
582-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Correlation between the results of glucocorticoid therapy and in vitro effect of glucocorticoids on monocytes in asthma.
pubmed:affiliation
M. F. Vladimirskii Moscow Regional Clinical Research Institute, Russian Academy of Medical Sciences, Moscow.
pubmed:publicationType
Journal Article