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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-8-25
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pubmed:abstractText |
Proteinuria is a significant independent determinant of the progression of chronic renal diseases. It induces an increased synthesis of angiotensin II, endothelin and profibrogenic growth factors, such as transforming growth factor-beta (TGF-beta), by mesangial and tubular cells. The antiproteinuric effect of angiotensin-converting enzyme inhibitors (ACEIs) in diabetic and non-diabetic nephropathies predicts long-term renoprotection afforded by these drugs. Angiotensin II receptor antagonists are renoprotective in patients with type 2 diabetes, but studies about their effect in non-diabetic proteinuric nephropathies are very scarce.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0931-0509
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pubmed:author |
pubmed-author:AguirreRománR,
pubmed-author:AndradeCarlos FernándezCF,
pubmed-author:AraJorge MartínezJM,
pubmed-author:AriasManuelM,
pubmed-author:BernisCarmenC,
pubmed-author:CampistolJose MaríaJM,
pubmed-author:GalceranJose MaríaJM,
pubmed-author:LuñoJoséJ,
pubmed-author:MarínRafaelR,
pubmed-author:MoraJoseJ,
pubmed-author:PovedaRafaelR,
pubmed-author:PragaManuelM,
pubmed-author:PratMarti VallesMV,
pubmed-author:RiveraFranciscoF
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1806-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12937228-Adult,
pubmed-meshheading:12937228-Amlodipine,
pubmed-meshheading:12937228-Angiotensin Receptor Antagonists,
pubmed-meshheading:12937228-Antihypertensive Agents,
pubmed-meshheading:12937228-Calcium Channel Blockers,
pubmed-meshheading:12937228-Diabetes Mellitus,
pubmed-meshheading:12937228-Double-Blind Method,
pubmed-meshheading:12937228-Female,
pubmed-meshheading:12937228-Humans,
pubmed-meshheading:12937228-Kidney Diseases,
pubmed-meshheading:12937228-Losartan,
pubmed-meshheading:12937228-Male,
pubmed-meshheading:12937228-Middle Aged,
pubmed-meshheading:12937228-Prospective Studies,
pubmed-meshheading:12937228-Proteinuria,
pubmed-meshheading:12937228-Transforming Growth Factor beta,
pubmed-meshheading:12937228-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trial.
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pubmed:affiliation |
Hospital 12 de Octubre, Madrid, Hospital Virgen del Rocio, Sevilla, Hospital Gregorio Marañón, Madrid, Spain. mpragat@senefro.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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