Linked Life Data

12935899

Source:http://linkedlifedata.com/resource/pubmed/id/12935899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2003-8-25
pubmed:abstractText
A deterministic computer model of the signal transduction pathway mediating bacterial chemotaxis was used to examine the variation in both unstimulated swimming behaviour and adaptation time to stimuli in clonal populations of cells. Copy numbers of proteins in the pathway were computed from a simplified model of transcription and translation that predicts greater-than-Poissonian statistics. Simulated and experimental individuality data could be brought into good agreement on varying the noise strength of the protein copy number distributions. In the simulations, all the proteins in the pathway are involved to a significant degree in the appearance of phenotypic diversity, although there is a modest decrease in influence with increasing copy number.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
550
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Noise in gene expression as the source of non-genetic individuality in the chemotactic response of Escherichia coli.
pubmed:affiliation
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. mdl22@cus.cam.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't