Linked Life Data

12935609

Source:http://linkedlifedata.com/resource/pubmed/id/12935609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-8-25
pubmed:abstractText
We examined changes in mRNA expression patterns for proinflammatory cytokines and growth factors in blood samples after application of a tourniquet to the rat hind limb. Slight upregulations of interferon (IFN)-gamma, macrophage colony-stimulating factor (M-CSF) and transforming growth factor (TGF)-beta1 mRNA began at 2h after tourniquet application and were short-lived. The levels of activating transcription factor (ATF)-3, a stress-inducible gene, had increased at 1h after tourniquet application. No significant expression of interleukin (IL)-6 mRNA was observed in most samples. There were no significant temporal changes in the levels of IL-1beta, cardiotrophin (CT)-1 mRNA compared to the control levels, but, downregulation of gp130, a receptor of the IL-6 family, began at 1h after tourniquet application. Nerve growth factor (NGF) mRNA gradually increased and reached a significantly high level at 4h after application of the tourniquet. Gene expression induction in blood leukocytes occurred soon after application of the tourniquet and was short-lived. The transient mRNA expressions probably trigger secondary events that may be beneficial to wound repair and regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1344-6223
pubmed:author
pubmed:issnType
Print
pubmed:volume
5 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S275-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12935609-Activating Transcription Factor 3, pubmed-meshheading:12935609-Animals, pubmed-meshheading:12935609-Gene Expression, pubmed-meshheading:12935609-Hindlimb, pubmed-meshheading:12935609-Interferon-gamma, pubmed-meshheading:12935609-Leukocytes, pubmed-meshheading:12935609-Macrophage Colony-Stimulating Factor, pubmed-meshheading:12935609-Male, pubmed-meshheading:12935609-Muscle, Skeletal, pubmed-meshheading:12935609-Nerve Growth Factors, pubmed-meshheading:12935609-RNA, Messenger, pubmed-meshheading:12935609-Rats, pubmed-meshheading:12935609-Rats, Wistar, pubmed-meshheading:12935609-Reperfusion Injury, pubmed-meshheading:12935609-Transcription Factors, pubmed-meshheading:12935609-Transforming Growth Factor beta, pubmed-meshheading:12935609-Transforming Growth Factor beta1
pubmed:year
2003
pubmed:articleTitle
Changes in mRNA expression patterns for cytokines in blood leukocytes of a rat tourniquet model.
pubmed:affiliation
Department of Legal Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. sumiko@fmu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't