Linked Life Data

12934182

Source:http://linkedlifedata.com/resource/pubmed/id/12934182

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pubmed-article:12934182pubmed:abstractTextWe tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).lld:pubmed
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pubmed-article:12934182pubmed:articleTitlePulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults.lld:pubmed
pubmed-article:12934182pubmed:affiliationWellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi. sgordon@mlw.medcol.mwlld:pubmed
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pubmed-article:12934182pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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