rdf:type |
|
lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0021027,
umls-concept:C0021051,
umls-concept:C0038410,
umls-concept:C0086418,
umls-concept:C0205349,
umls-concept:C0392756,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2709248,
umls-concept:C2911692
|
pubmed:issue |
5
|
pubmed:dateCreated |
2003-8-22
|
pubmed:abstractText |
We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0022-1899
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
188
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
666-70
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:12934182-AIDS-Related Opportunistic Infections,
pubmed-meshheading:12934182-Adult,
pubmed-meshheading:12934182-Antibodies, Bacterial,
pubmed-meshheading:12934182-Antibody Specificity,
pubmed-meshheading:12934182-Bacterial Capsules,
pubmed-meshheading:12934182-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12934182-Female,
pubmed-meshheading:12934182-HIV Infections,
pubmed-meshheading:12934182-Humans,
pubmed-meshheading:12934182-Immunoglobulin G,
pubmed-meshheading:12934182-Immunoglobulin M,
pubmed-meshheading:12934182-Lung,
pubmed-meshheading:12934182-Malawi,
pubmed-meshheading:12934182-Male,
pubmed-meshheading:12934182-Pneumococcal Infections,
pubmed-meshheading:12934182-Respiratory Tract Infections,
pubmed-meshheading:12934182-Streptococcus pneumoniae
|
pubmed:year |
2003
|
pubmed:articleTitle |
Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults.
|
pubmed:affiliation |
Wellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi. sgordon@mlw.medcol.mw
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|