Linked Life Data

12932818

Source:http://linkedlifedata.com/resource/pubmed/id/12932818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-8-22
pubmed:abstractText
We measured the reduction by nociceptin of the [Ca(2+)](i) transient triggered by depolarization in acutely dissociated neurones of the rat dorsal raphe and periventricular hypothalamic nuclei that express NPFF(2) and NPFF(1) receptors, respectively, in the absence and presence of 10 nM of NPA-NPFF or NPVF, two peptides selective for NPFF(2) and NPFF(1) receptors, respectively. In dorsal raphe neurones, NPA-NPFF reduces the inhibition of Ca(2+) conductances by nociceptin while NPVF is inactive. In periventricular hypothalamic neurones, both peptides reduce the inhibition of Ca(2+) transients by nociceptin, NPVF having a significantly larger effect than NPA-NPFF. These results demonstrate that activation of both NPFF(1) and NPFF(2) receptors has the same cellular anti-opioid effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
348
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Neuropeptide FF receptors 1 and 2 exert an anti-opioid activity in acutely dissociated rat dorsal raphe and periventricular hypothalamic neurones.
pubmed:affiliation
Institut de Pharmacologie et de Biologie Structurale (CNRS, UMR 5089), 205 route de Narbonne, 31077 Cedex 04, Toulouse, France. michel.roumy@ipbs.fr
pubmed:publicationType
Journal Article, Comparative Study