|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-8-22
|
|
pubmed:abstractText |
T cells develop through distinct stages directed by a series of signals. We explored the roles of SWI/SNF-like BAF chromatin remodeling complexes in this process by progressive deletion of the ATPase subunit, Brg, through successive stages of early T cell development. Brg-deficient cells were blocked at each of the developmental transitions examined. Bcl-xL overexpression suppressed cell death without relieving the developmental blockades, leading to the accumulation of Brg-deleted cells that were unexpectedly cell cycle arrested. These defects resulted partly from the disruptions of pre-TCR and potentially Wnt signaling pathways controlling the expression of genes such as c-Kit and c-Myc critical for continued development. Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Bcl2l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/Smarca2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smarca4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
169-82
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12932351-Adenosine Triphosphatases,
pubmed-meshheading:12932351-Animals,
pubmed-meshheading:12932351-Cell Cycle,
pubmed-meshheading:12932351-Cell Differentiation,
pubmed-meshheading:12932351-Chromatin,
pubmed-meshheading:12932351-DNA Helicases,
pubmed-meshheading:12932351-Genes, myc,
pubmed-meshheading:12932351-Mice,
pubmed-meshheading:12932351-Mice, Knockout,
pubmed-meshheading:12932351-Mice, Transgenic,
pubmed-meshheading:12932351-Models, Immunological,
pubmed-meshheading:12932351-Nuclear Proteins,
pubmed-meshheading:12932351-Nucleic Acid Denaturation,
pubmed-meshheading:12932351-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12932351-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:12932351-Signal Transduction,
pubmed-meshheading:12932351-T-Lymphocytes,
pubmed-meshheading:12932351-Transcription Factors,
pubmed-meshheading:12932351-bcl-X Protein
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development.
|
|
pubmed:affiliation |
Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
