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pubmed-article:12932143pubmed:abstractTextAntifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.lld:pubmed
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pubmed-article:12932143pubmed:articleTitleAcetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.lld:pubmed
pubmed-article:12932143pubmed:affiliationNational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. xli@olemiss.edulld:pubmed
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