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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
8
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pubmed:dateCreated |
2003-8-22
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pubmed:abstractText |
Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0163-3864
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1132-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12932143-Amphotericin B,
pubmed-meshheading:12932143-Antifungal Agents,
pubmed-meshheading:12932143-Candida albicans,
pubmed-meshheading:12932143-Drug Resistance, Microbial,
pubmed-meshheading:12932143-Fatty Acids, Monounsaturated,
pubmed-meshheading:12932143-Fluconazole,
pubmed-meshheading:12932143-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:12932143-Methylation,
pubmed-meshheading:12932143-Microbial Sensitivity Tests,
pubmed-meshheading:12932143-Molecular Structure,
pubmed-meshheading:12932143-Peru,
pubmed-meshheading:12932143-Plant Roots,
pubmed-meshheading:12932143-Sphingolipids
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pubmed:year |
2003
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pubmed:articleTitle |
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
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pubmed:affiliation |
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. xli@olemiss.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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