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rdf:type |
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lifeskim:mentions |
umls-concept:C0002844,
umls-concept:C0010453,
umls-concept:C0018061,
umls-concept:C0021463,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0229535,
umls-concept:C0391871,
umls-concept:C0443199,
umls-concept:C0680255,
umls-concept:C0851285,
umls-concept:C1283071,
umls-concept:C1963578
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
1993-4-6
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|
pubmed:abstractText |
Using in vitro bioassays and radioimmunoassays, the authors examined the interactions between purified 32kD ovine inhibin, testosterone, and dihydrotestosterone on basal and GnRH-stimulated secretion of gonadotropins in primary rat pituitary cell cultures. This study demonstrates that inhibin and androgens: 1) differentially regulate gonadotropin levels, 2) cause changes in the amounts of bioactive and immunoactive FSH and LH released. In conclusion, differences in bio- and immuno-FSH and LH secretion suggest that the endocrine milieu results in not only quantitative but qualitative changes in the secreted gonadotropin isoforms.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-3635
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1293132-Androgens,
pubmed-meshheading:1293132-Animals,
pubmed-meshheading:1293132-Aromatase,
pubmed-meshheading:1293132-Cells, Cultured,
pubmed-meshheading:1293132-Dihydrotestosterone,
pubmed-meshheading:1293132-Drug Interactions,
pubmed-meshheading:1293132-Female,
pubmed-meshheading:1293132-Follicle Stimulating Hormone,
pubmed-meshheading:1293132-Gonadotropin-Releasing Hormone,
pubmed-meshheading:1293132-Gonadotropins,
pubmed-meshheading:1293132-Granulosa Cells,
pubmed-meshheading:1293132-Inhibins,
pubmed-meshheading:1293132-Leydig Cells,
pubmed-meshheading:1293132-Luteinizing Hormone,
pubmed-meshheading:1293132-Male,
pubmed-meshheading:1293132-Pituitary Gland,
pubmed-meshheading:1293132-Rats,
pubmed-meshheading:1293132-Rats, Sprague-Dawley,
pubmed-meshheading:1293132-Testosterone
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pubmed:articleTitle |
Differential regulation in the release of bioactive versus immunoactive gonadotropins from cultured rat pituitary cells by inhibin and androgens.
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pubmed:affiliation |
Department of Medicine, VA Medical Center, Seattle, Washington 98108.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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