|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-8-21
|
|
pubmed:abstractText |
The mechanism of osteoblast formation by a novel PDE4 inhibitor, XT-611, was studied in the in vitro bone marrow culture system. The compound potentiated the osteoblast differentiation through accumulation of cyclic AMP after autocrine stimulation of EP4 receptor by PGE2 in pro-osteoblastic cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-AMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/3,4-dipropyl-4,5,7,8-tetrahydro-3H-i...,
http://linkedlifedata.com/resource/pubmed/chemical/Anabolic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Purines
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0884-0431
|
|
pubmed:author |
pubmed-author:KasugaiShoheiS,
pubmed-author:MiyamotoKen-ichiK,
pubmed-author:MoritaniShuzoS,
pubmed-author:OchiaiEijiE,
pubmed-author:SaitohYukieY,
pubmed-author:SawanishiHiroyukiH,
pubmed-author:SuzukiHirokazuH,
pubmed-author:WakiYoshihiroY,
pubmed-author:YamagamiHideomiH,
pubmed-author:YamamotoShinyaS,
pubmed-author:YokogawaKoichiK
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1471-7
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12929936-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:12929936-Anabolic Agents,
pubmed-meshheading:12929936-Animals,
pubmed-meshheading:12929936-Bone Marrow Cells,
pubmed-meshheading:12929936-Cells, Cultured,
pubmed-meshheading:12929936-Cyclic AMP,
pubmed-meshheading:12929936-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:12929936-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:12929936-Dinoprostone,
pubmed-meshheading:12929936-Male,
pubmed-meshheading:12929936-Mice,
pubmed-meshheading:12929936-Osteoblasts,
pubmed-meshheading:12929936-Osteogenesis,
pubmed-meshheading:12929936-Phosphodiesterase Inhibitors,
pubmed-meshheading:12929936-Purines,
pubmed-meshheading:12929936-Rats,
pubmed-meshheading:12929936-Rats, Wistar
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Prostaglandin E2-mediated anabolic effect of a novel inhibitor of phosphodiesterase 4, XT-611, in the in vitro bone marrow culture.
|
|
pubmed:affiliation |
Department of Hospital Pharmacy, School of Medicine, Kanazawa University, Kanazawa, Japan. miyaken@pharmacy.m.kanazawa-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
