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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0005953,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0029433,
umls-concept:C0083031,
umls-concept:C0085828,
umls-concept:C0162597,
umls-concept:C0185117,
umls-concept:C0205216,
umls-concept:C0221099,
umls-concept:C0332281,
umls-concept:C0441655,
umls-concept:C2911684
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-8-21
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|
pubmed:abstractText |
Expression of an osteogenic cytokine, IL-11, is decreased in SAMP6. We show here that IL-11 transcription largely depends on AP-1 transcription factors, activities of which are decreased in SAMP6 as well as aged ICR mice. Therefore, diminished AP-1 activity and the resultant decline in IL-11 expression may play a role in impaired bone formation in the aged.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1461-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12929935-5' Untranslated Regions,
pubmed-meshheading:12929935-Aging,
pubmed-meshheading:12929935-Animals,
pubmed-meshheading:12929935-Base Sequence,
pubmed-meshheading:12929935-Bone Marrow Cells,
pubmed-meshheading:12929935-Cell Line,
pubmed-meshheading:12929935-Cloning, Molecular,
pubmed-meshheading:12929935-Gene Expression Regulation,
pubmed-meshheading:12929935-Humans,
pubmed-meshheading:12929935-Interleukin-11,
pubmed-meshheading:12929935-Mice,
pubmed-meshheading:12929935-Mice, Inbred ICR,
pubmed-meshheading:12929935-Molecular Sequence Data,
pubmed-meshheading:12929935-Osteogenesis,
pubmed-meshheading:12929935-Promoter Regions, Genetic,
pubmed-meshheading:12929935-Protein Binding,
pubmed-meshheading:12929935-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:12929935-RNA, Messenger,
pubmed-meshheading:12929935-Sequence Alignment,
pubmed-meshheading:12929935-Stromal Cells,
pubmed-meshheading:12929935-Transcription Factor AP-1
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pubmed:year |
2003
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pubmed:articleTitle |
Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice.
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pubmed:affiliation |
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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