|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-8-21
|
|
pubmed:abstractText |
The paired-like homeoprotein, Cart1, is involved in skeletal development. We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in other homeoproteins. Acetylation of this residue increases the interaction between p300/CBP and Cart1 and enhances its transcriptional activation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ALX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Alx1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Alx1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E1A-Associated p300 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Ep300 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ep300 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0884-0431
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1419-29
|
|
pubmed:dateRevised |
2011-10-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12929931-Acetylation,
pubmed-meshheading:12929931-Amino Acid Sequence,
pubmed-meshheading:12929931-Animals,
pubmed-meshheading:12929931-Binding Sites,
pubmed-meshheading:12929931-Cell Line,
pubmed-meshheading:12929931-DNA-Binding Proteins,
pubmed-meshheading:12929931-E1A-Associated p300 Protein,
pubmed-meshheading:12929931-Homeodomain Proteins,
pubmed-meshheading:12929931-Humans,
pubmed-meshheading:12929931-Lysine,
pubmed-meshheading:12929931-Mice,
pubmed-meshheading:12929931-Molecular Sequence Data,
pubmed-meshheading:12929931-Nuclear Proteins,
pubmed-meshheading:12929931-Protein Binding,
pubmed-meshheading:12929931-Protein Structure, Tertiary,
pubmed-meshheading:12929931-Rats,
pubmed-meshheading:12929931-Trans-Activators,
pubmed-meshheading:12929931-Transcriptional Activation
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.
|
|
pubmed:affiliation |
Division of Orthopaedic Pathomechanism, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
|
|
pubmed:publicationType |
Journal Article
|
