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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0439097,
umls-concept:C0591833,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1552861,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2587213,
umls-concept:C2900461
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pubmed:issue |
5
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pubmed:dateCreated |
2003-8-20
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pubmed:abstractText |
West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in gammadelta T cells are more susceptible to WN virus infection. TCRdelta(-/-) mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, gammadelta T cells expanded significantly during WN virus infection, produced IFN-gamma in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of gammadelta T cells to TCRdelta(-/-) mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-gamma-producing gammadelta T cells. These data demonstrate a distinct role for gammadelta T cells in the control of and prevention of mortality from murine WN virus infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2524-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12928402-Adoptive Transfer,
pubmed-meshheading:12928402-Animals,
pubmed-meshheading:12928402-Blood,
pubmed-meshheading:12928402-Cell Division,
pubmed-meshheading:12928402-Cells, Cultured,
pubmed-meshheading:12928402-Cytotoxicity, Immunologic,
pubmed-meshheading:12928402-Encephalitis, Viral,
pubmed-meshheading:12928402-Female,
pubmed-meshheading:12928402-Genes, T-Cell Receptor beta,
pubmed-meshheading:12928402-Genes, T-Cell Receptor delta,
pubmed-meshheading:12928402-Genetic Predisposition to Disease,
pubmed-meshheading:12928402-Interferon-gamma,
pubmed-meshheading:12928402-Lymphoid Tissue,
pubmed-meshheading:12928402-Mice,
pubmed-meshheading:12928402-Mice, Inbred C57BL,
pubmed-meshheading:12928402-Mice, Knockout,
pubmed-meshheading:12928402-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:12928402-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12928402-Severity of Illness Index,
pubmed-meshheading:12928402-T-Lymphocyte Subsets,
pubmed-meshheading:12928402-Viral Load,
pubmed-meshheading:12928402-West Nile Fever,
pubmed-meshheading:12928402-West Nile virus
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pubmed:year |
2003
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pubmed:articleTitle |
IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection.
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pubmed:affiliation |
Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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