| pubmed-article:12928051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C1704829 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:12928051 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:12928051 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12928051 | pubmed:dateCreated | 2003-8-20 | lld:pubmed |
| pubmed-article:12928051 | pubmed:abstractText | Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients compared to controls and significantly increased the risk of AD. Moreover, the -174 CC genotype was associated with a high risk of the disease in women. The D allele of a variable number of tandem repeat (VNTR) was in strong linkage disequilibrium with the -174 C allele and slightly increased AD risk. On the other hand, the frequency of the VNTR C allele was decreased in patients with AD and was negatively associated with the risk of developing AD. Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine. | lld:pubmed |
| pubmed-article:12928051 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12928051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928051 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12928051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12928051 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12928051 | pubmed:issn | 0197-4580 | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:OlivieriFabio... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:BonafèMassimi... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:CavalloneLuca... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:FranceschiCla... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:MasliahElieze... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:GrimaldiLuigi... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:LicastroFeder... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:ChiappelliMar... | lld:pubmed |
| pubmed-article:12928051 | pubmed:author | pubmed-author:GiovaniettiSi... | lld:pubmed |
| pubmed-article:12928051 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12928051 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:12928051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12928051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12928051 | pubmed:pagination | 921-6 | lld:pubmed |
| pubmed-article:12928051 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12928051 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12928051 | pubmed:articleTitle | Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. | lld:pubmed |
| pubmed-article:12928051 | pubmed:affiliation | Department of Experimental Pathology, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy. licastro@alma.unibo.it | lld:pubmed |
| pubmed-article:12928051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12928051 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12928051 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12928051 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:12928051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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