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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-8-20
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pubmed:abstractText |
Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients compared to controls and significantly increased the risk of AD. Moreover, the -174 CC genotype was associated with a high risk of the disease in women. The D allele of a variable number of tandem repeat (VNTR) was in strong linkage disequilibrium with the -174 C allele and slightly increased AD risk. On the other hand, the frequency of the VNTR C allele was decreased in patients with AD and was negatively associated with the risk of developing AD. Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0197-4580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
921-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12928051-3' Flanking Region,
pubmed-meshheading:12928051-Aged,
pubmed-meshheading:12928051-Aging,
pubmed-meshheading:12928051-Alzheimer Disease,
pubmed-meshheading:12928051-Analysis of Variance,
pubmed-meshheading:12928051-Apolipoprotein E4,
pubmed-meshheading:12928051-Apolipoproteins E,
pubmed-meshheading:12928051-Female,
pubmed-meshheading:12928051-Frontal Lobe,
pubmed-meshheading:12928051-Gene Frequency,
pubmed-meshheading:12928051-Genetic Predisposition to Disease,
pubmed-meshheading:12928051-Humans,
pubmed-meshheading:12928051-Interleukin-6,
pubmed-meshheading:12928051-Italy,
pubmed-meshheading:12928051-Linkage Disequilibrium,
pubmed-meshheading:12928051-Male,
pubmed-meshheading:12928051-Middle Aged,
pubmed-meshheading:12928051-Minisatellite Repeats,
pubmed-meshheading:12928051-Polymorphism, Genetic,
pubmed-meshheading:12928051-Promoter Regions, Genetic,
pubmed-meshheading:12928051-Reference Values,
pubmed-meshheading:12928051-Risk Factors,
pubmed-meshheading:12928051-Sex Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain.
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pubmed:affiliation |
Department of Experimental Pathology, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy. licastro@alma.unibo.it
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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