Linked Life Data

12926098

Source:http://linkedlifedata.com/resource/pubmed/id/12926098

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-8-20
pubmed:abstractText
We investigated the sub-clinical lung injury in patients with breast cancer after chemotherapy by technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan. Fifty patients who underwent surgical resection for breast cancers were divided into two groups, those who received a combination of adjuvant chemotherapy and those who did not. Group 1 consisted of 25 patients who received adjuvant chemotherapy and group 2 consisted of 25 patients who did not receive adjuvant chemotherapy. Tc-99m HMPAO lung scan was performed in each patient and the degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratio). None of the 50 patients had positive plain chest radiograph (CXR) and pulmonary function test (PFT) findings. The results showed a significantly higher L/L ratio in the group 1 patients (0.57 +/- 0.13) than in the group 2 patients (0.32 +/- 0.05). We conclude that chemotherapeutic drugs may result in pulmonary vascular endothelium damage and that Tc-99m HMPAO lung scan has the potential to be a sensitive, objective and non-invasive method to detect sub-clinical lung injury of patients with breast cancers after chemotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3505-7
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed:articleTitle
Usefulness of technetium-99m hexamethylpropylene amine oxime lung scan to detect sub-clinical lung injury of patients with breast cancer after chemotherapy.
pubmed:affiliation
Department of Nuclear Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Clinical Trial